Expression of Tspan-1 in benign and malignant lesions of the colon
10.3760/cma.j.issn.1007-631X.2010.09.020
- VernacularTitle:Tspan-1在结直肠肿瘤组织中的表达及其意义
- Author:
Ting LI
;
Meirong XU
;
Qiang SHI
;
Jianwei ZHU
- Publication Type:Journal Article
- Keywords:
Colorectal neoplasmas;
Gene expression;
Pathology,clinical;
Tspan-1
- From:
Chinese Journal of General Surgery
2010;25(9):751-754
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the protein expression of Tspan-1 gene in colorectal carcinoma,and investigate the relationship between the expression and biologic behavior of colorectal carcinoma. Methods Immunohistochemical ELIVISION two-step method was used to detect the protein expression of Tspan-1 gene in 80 cases of colorectal carcinoma,13 cases of colorectal adenoma and 27 cases of normal colorectal tissues. Results The positive expression rate of Tspan-1 in colorectal carcinoma was significantly higher than that in colorectal adenoma and normal colorectal tissues,there was significant difference in the expression among the three groups.The positive expression rate of Tspan-1 was 90% in colorectal carcinoma,23% in colorectal adenoma and 7% in normal colorectal tissues (P ＜ 0.01).The positive expression rate of Tspan-1 in poor and moderately differentiated carcinoma was significantly higher than that in well-differentiated carcinoma (P ＜ 0.01).The expression of Tspan-1 was significantly associated with lymph node metastasis (P＜0.01),and with the 5-year survival rate of colorectal carcinoma patients,with also TNM stage and the depth of tumor invasion (P ＜0.01),and while it was not associated with gender,age,location,tumor size,and type (P ＞ 0.05). Conclusion The expression of Tspan-1 gene could be as a marker predicting the prodnosis of colorectal adenocarcinoma patients,also it may play an important role in the pathogenesis of colorectal adenoma.
