Clinical therapeutic observation of doxazosin mesylate in treatment of vesical spasm in 256 patients undergoing surgery for relieving bladder outlet obstruction

VernacularTitle:甲磺酸多沙唑嗪缓释剂治疗膀胱出口梗阻术后膀胱痉挛的临床观察
Author: Shan HUANG ; Junping YANG ; Quan CHEN
Publication Type:Journal Article
Keywords: Urinary bladder,overactive; Urirary bladder neck obstruction; Doxazosin; Urologic surgical procedurec
From: Chinese Journal of Geriatrics 2010;29(9):748-749
CountryChina
Language:Chinese
Abstract: Objective To study the preventive and therapeutic effect of doxazosin mesylate (Cardura) in the management of vesical spasm. Methods Two hundred and fifty six cases were randomized into two groups: the study group was given Cardura 4 mg at bedtime, while the control group was given probanthine 15 mg twice a day. All the patients were given 8 ng of Vitamin Ks three times a day. Results There was significant difference in the incidence of vesical spasm between study group and control group (P＜0.01). Conclusions Cardura can decrease the urethral closure pressure, and reduce excitability of bladder detrusor muscle. So it is effective for the relief of vesical spasm.