Correlation study on mast cells' property and PUF scale in interstitial cystitis
10.3760/cma.j.issn.1000-6702.2010.09.015
- VernacularTitle:肥大细胞特征检测与盆腔症状评分联合应用——间质性膀胱炎诊断标准研究
- Author:
Xu WANG
;
Wei ZHANG
;
Ruifa HAN
- Publication Type:Journal Article
- Keywords:
Cystitis,interstitial;
Mast cells;
Reference standards
- From:
Chinese Journal of Urology
2010;31(9):618-620
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the mast cells' property and the level of pelvic pain, urgency and frequency (PUF) scale in urinary bladder between interstitial cystitis (IC) patients and controls.Methods Eighteen cystoscopy biopsy specimens of interstitial cystitis patients and 12 controls were stained with 0.5% toluidine blue and immobilizated with Osmic Acid. Then the mast cells were observed and counted with light microscope and transmission electron microscope. The PUF scale and the number of mast cells between the 2 groups were compared. Results The mast cell's number of the interstitial cystitis samples(28-76 pieces/mm2) was significantly higher than that of the non IC persons' bladder tissues(7-15 pieces/mm2) (Z=3.927,P＜0.01). 75.3% mast cells were in a state of being activated degranulation. The PUF scale of IC patients( 17-35 scores)was significantly higher than that of the non IC persons' (0-8 scores) (t=14.736,P＜0.01). The PUF scale of the patient group did not have a linear IC relation with the mast cell's infiltrated number among the specimens (rs=-0.618,P=0.601). Conclusions Mast cell infiltration may be one of the characteristic pathological manifestations of IC. The association of mast cell infiltration and the PUF scale may be a new diagnosis criteria for IC.
