Literature review on treatment of type 2 diabetic foot cases with umbilical cord blood mesenchymal stem cell transplantation
10.3760/cma.j.issn.1008-6315.2010.09.007
- VernacularTitle:脐血间充质干细胞移植治疗糖尿病足二例并文献复习
- Author:
Huaqiang YANG
;
Dongsheng LI
;
Ling DU
;
Yahong YUAN
;
Hua JIANG
- Publication Type:Journal Article
- Keywords:
Diabetic foot;
Transplantation;
Umbilical cord blood mesenchymal stem cell
- From:
Clinical Medicine of China
2010;26(9):918-920
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical effect and safety of umbilical cord blood mesenchymal stem cell(UCB-MSC) transplantation in the treatment of diabetic foot. Methods UCB-MSC suspension (cell concentration (3 -7) × 107/L,0.3 -0.5 ml per point) was injected into multiple spots on affected lower limb with a 3 cm × 3 cm istance among each point. Demixing injection could be performed in regions with multilayer muscles. Clinical symptoms and related index were routinely observed from the first day to three months after operation. Results After three months of UCB-MSC transplantation, pain of patients was relieved, skin temperature increased, intermittent claudication ameliorated, ulcer healed, ankle-brachial index and transcutaneous partial pressure of oxygen increased. The lower extremity lesions showed an abundant collateral vessel formation after the treatment in 2 patients by angiography. Both patients had no severe complications and adverse reactions, none underwent amputation. Conclusions Umbilical cord blood mesenchymal stem cell transplantation is a safe and effective treatment of diabetic lower limb ischemic disease, which can exempt the patient from amputation and improve their quality of life.
