Screening for the inherited metabolic diseases in infants with cholestasis and changing pattern of diagnosis
10.3760/cma.j.issn.1000-6699.2010.09.011
- VernacularTitle:遗传代谢病的筛查与婴儿胆汁淤积病因诊断的变化
- Author:
Xiaoyu LI
;
Huamei MA
;
Hongshan CHEN
;
Yanhong LI
;
Zhenyu SHEN
;
Minlian DU
- Publication Type:Journal Article
- Keywords:
Infant,cholestasis;
Cytomegalovirus;
Inherited metabolic disease;
Citrin deficiency
- From:
Chinese Journal of Endocrinology and Metabolism
2010;26(9):774-777
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changing pattern of diagnosis of infantile cholestasis after screening the inherited metabolic diseases in infants with cholestasis. Methods Infants under 12 months with cholestasis were identified retrospectively from hospital records from Jan. 1996 to Dec. 2007. The data were retrieved from the medical records and analyzed by focusing particularly on the changing etiology of cholestasis and inherited metabolic diseases in these infants after performing routine screening and diagnostic procedures. Results Among 421 infants identified as having cholestasis during 12-years study period, the common causes of infantile cholestasis were cytomegalovirus (CMV) infection (36. 11% ), bile duct hypoplasia or congenital biliary atresia (31.59%), metabolic disease (8.08%), miscellaneous (10.69%), and unknown ( 13.54% ). The proportion of infants with metabolic diseases after screening increased 16 folds compared with before screening( 15.76% vs 0. 92% ,P<0. 01 ), whereas the proportion of infants with unknown cause decreased from 17.43% to 9.36% (P<0.05). There was no significant change in the proportions of CMV infection, congenital biliary atresia, and miscellaneous causes. The major metabolic diseases of 34 infants included citrin deficiency (41. 18% ) and tyrosinemia (23.53%), followed by galactosemia and progressive familial intrahepatic cholestasis (8. 82% )etc. Conclusions Inherited metabolic disease has become an important cause of infantile cholestasis, which is mainly due to citrin deficiency. Therefore, it is necessary to set a routing screening of citrin deficiency in infants with cholestasis.
