Influence of irbesartan on urine microalbuminuria in elderly patients with morning blood pressure surge hypertension
10.3760/cma.j.issn.1008-6315.2010.09.006
- VernacularTitle:厄贝沙坦对老年高血压晨峰患者微量白蛋白尿的影响及降压疗效
- Author:
Xumei GUO
;
Fengyun MA
;
Huiping GUO
;
Junfang BI
- Publication Type:Journal Article
- Keywords:
Morning blood pressure surge;
Irbesartan;
Ambulatory blood pressure;
Urine microalbuminuria
- From:
Clinical Medicine of China
2010;26(9):916-918
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence of irbesartan taken before bedtime on morning blood pressure surge and urine microalbuminuria in elderly patients with essential hypertension. Methods Ninety-two patients with uncontrolled hypertension were recruited in this study and their 24-hour ambulatory blood pressure monitoring profiles were collected for analysis. After irbesartan taken before bedtime, its influence on general blood pressure, morning blood pressure surge and urine microalbuminuria was observed. Results Before irbesartan treatment,the average 24-hour ambulatory blood pressure was(140.1 ± 12. 7)mm Hg, the morning blood pressure surge was (45.6 ± 10.8) mm Hg, urine microalbuminuria level was (58.6 ± 3.7) mg/L. After irbesartan treatment,the average 24-hour ambulatory blood pressure decreased to (129. 5 t 11.8) mm Hg (t = 3.18, P ＜ 0.05), the morning blood pressure surge decreased to(14. 2 ±4. 1)mm Hg(t =5.74,P ＜0.01) ,urine microalbuminuria level decreased to(31.7±3.1)mg/L(t =5.24,P＜0.01).Conclusions Irbesartan can effectively reduce the peak morning blood pressure,improve achievement ratio of blood pressure control, decrease urine microalbuminuria level in elderly patients essential hypertension.
