The expression difference of serum bilirubin and uric acid in carotid artery plaque formation of patients with ischemic cerebral vascular disease
10.3760/cma.j.issn.1008-6315.2010.09.016
- VernacularTitle:缺血性脑血管疾病患者颈动脉斑块形成过程中胆红素及尿酸的表达差异
- Author:
Yun LUO
;
Jingwei LI
;
Hairong ZHU
;
Dening GUAN
;
Yun XU
- Publication Type:Journal Article
- Keywords:
Carotid artery plaque;
Ischemic cerebral vascular disease;
Bilirubin;
Uric acid
- From:
Clinical Medicine of China
2010;26(9):943-945
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the possible roles of serum bilirubin and uric acid in the course of carotid artery intima thicken/plaque formation. Methods Patients with ischemic cerebral vascular disease were divided into the control group, intima thicken group and plaque formation group according to the carotid artery intimamedia thickness (IMT) examination by B-mode ultrasound. The serum bilirubin and uric acid were detected by Automatic Chemistry Analyzer. Results The serum level of uric acid of (391.22 ± 27.52) μmol/L in intima thicken group was significantly higher than that in the control group and plaque formation group((307.32 ± 13.68)μmol/L and (327.84 ± 17.96)μmol/L, P ＜ 0.05). The serum level of indirect bilirubin and total bilirubin in plaque formation group was (10.96 ± 0.58) μmol/L and (15.91 ± 0.71) μmol/L respecitively, which were significantly lower than those in the control group ((15.09 ± 2.21) μmol/L and (20.59 ± 2.43) μmol/L,respectively) and the intima thicken group((15.09 ± 2.21) μmol/L and (20.59 ± 2.43) μmol/L, respectively) (Psignificantly lower than that of (5.70 ± 0.28) μmol/L in the control group(P ＜ 0.05). Conclusions Bilirubin and uric acid play different roles in carotid artery plaque formation during different stage.
