Efficacy of ganciclovir combined with Bacillus Calmette-Guerin polysaccharide nucleic acid for the treatment of herpes zoster
10.3760/cma.j.issn.1673-4904.2010.27.009
- VernacularTitle:更昔洛韦联合卡介菌多糖核酸治疗带状疱疹疗效观察
- Author:
Juncheng LI
- Publication Type:Journal Article
- Keywords:
Herpes zoster;
Ganciclovir;
Treatment outcome;
Bacillus Calmette-Guerin polysaccharide and nucleic acid
- From:
Chinese Journal of Postgraduates of Medicine
2010;33(27):22-24
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical efficacy of ganciclovir combined with Bacillus Calmette-Guerin polysaccharide nucleic acid (BCG-PSN) for the treatment of herpes zoster. Methods Eighty-six cases with herpes zoster were randomly divided into study group and control group, 43 cases in each group. Patients of control group received simple ganciclovir treatment; while patients of the study group received BCG-PSN on this basis, then to observe and compare the efficacy, the repair time of skin lesions (herpes stopping, surface deposition), odynolysis time, remained neuralgia incidence and adverse reactions of two groups. Results Patients of two groups all completed the experiment successfully, no one withdraw from this trial because of no tolerance of drugs. The herpes stopping and surface deposition time and odynolysis time of study group were significantly shorter than those of control group, the difference was statistically significant (P＜0.05 ); the remained neuralgia incidence was significantly lower than that of control group,the difference was statistically significant (P＜0.05); the effective rate of study group in 14 days after treatment was 90.7% (39/43) and significantly higher than that of control group [74.4% (32/43)], the difference was statistically significant (P ＜ 0.05);there were no serious adverse reactions occurred in two groups. Conclusion Application of ganciclovir combined with BCG-PSN for the treatment of herpes zoster has certain efficacy, it is feasible and safe.
