Relationship between the level of plasma homocysteine and coronary calcification in patients with different blood glucose levels
10.3760/cma.j.issn.1008-6315.2010.09.020
- VernacularTitle:不同血糖水平患者同型半胱氨酸与冠状动脉钙化的关系
- Author:
Jiangrong ZHANG
;
Weisheng LU
;
Lingwei YU
;
Jing CHANG
;
Huimin YUAN
;
Dongxia LI
;
Xingwang GAO
- Publication Type:Journal Article
- Keywords:
Plasma homocysteine;
Coronary artery calcification score;
Diabetes
- From:
Clinical Medicine of China
2010;26(9):952-954
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the relationship between the level of plasma homocysteine and coronary calcification in patients with different blood glucose levels. Methods By measuring plasma homocysteine and coronary calcification in 30 cases of diagnosed diabetes (T2D) ,29 cases of diagnosed impaired glucose tolerance (IGT) in patients and 27 cases with normal, we compared the level of plasma homocysteine and coronary calcification in patients with different blood glucose levels. Results We found significant diffieronces among three groups of the level of plasms homocysteine and coronary calcification (P ＜ 0.01). The plasma homocysteine levels were(19.31 ±3.17) μmol/L, (13.85 ± 1.62) μmol/L, (9.80 ± 1.78) μmol/L in the T2D,IGT and normal groups,respectively. The coronary calcification scores were 207.80 ± 154.10,63.24 ± 10.46,14.47 ± 5.16 in the T2D, IGT and normal groups, respectively. The plasma homocysteine level and coronary calcification score increased with the glycosylated hemoglobin rise in the normal,IGT and T2D groups((4.51 ±0.48)%, (6.13 ±0.31)% and (7.69 ±0.81)%, respectively). Conclusions The plasma homocysteine level is a strong independent predictor of type 2 diabetes and also an important factor of coronary artery event occurrence and develepment.
