The white matter integrity of treatment-naive, first-episode paranoid schizophrenia: a diffusion tensor imaging study

VernacularTitle:首发未服药偏执型分裂症脑白质的弥散张量成像研究
Author: Qinling WEI ; Zhuang KANG ; Xianglan WANG ; Jinbei ZHANG ; Leijun LI ; Liarong ZHENG ; Zili HAN
Publication Type:Journal Article
Keywords: Paranoid schizophrenia; White matter; Diffusion tensor imaging; Thalamus; Insula lobe
From: Chinese Journal of Behavioral Medicine and Brain Science 2010;19(9):784-786
CountryChina
Language:Chinese
Abstract: Objective To explore the changes of the white matter integrity in paranoid schizophrenia.Methods Diffusion weighted images of the 19 patients' with paranoid schizophrenia and 30 healthy controls'whole brains were acquired with a single-shot echo planar imaging ( EPI ) sequence aligned to the straight axial plane. After preprocessed with DTI-studio and SPM5 software, the fractional anisotropy (FA) images of the two groups were compared by two-sample t-test with SPM5 software. Results Subjects of paranoid schizophrenia demonstrated reduced FA in the right thalamus white matter(x = 18 ,y = - 10,z = 14,cluster = 194, t= -3.27, P=0.000 ) and demonstrated increased FA in the right insula white matter ( x = 34, y = -10, z = 12, cluster = 113, t =4.50, P = 0.004 ). Conclusion Schizophrenia has conflicting changes of white matter integrity in some brain areas.