Effects of high fat and high salt diet on the growth and metabolism in juvenile rat

VernacularTitle:高脂高盐饮食对未成年鼠生长及代谢的影响
Author: Ying WEI ; Geli LIU ; Qingyan YANG ; Rongxiu ZHENG ; Tong WANG ; Pengli BAO ; Linjie YANG
Publication Type:Journal Article
Keywords: Metabolic syndrome X; Improper diet; Rats
From: Chinese Journal of Primary Medicine and Pharmacy 2010;17(16):2226-2228
CountryChina
Language:Chinese
Abstract: Objective To investigate effects of high fat-salt diet on change of growth and development,body fat distribution insulin sensitivity and associated metabolic indexes for juvenile rats. Methods 50 grams of male,female SD juvenile rats (3 weeks,just weaned) were randomly divided into 3 groups,12-14 animals in each group,were given routine diet (NC) and high fat diet (FC) and high fat-salt diet (FSC) .Then the body weight,,body length,abdominal circumference,blood pressure,visceral fat weight,plasma lipids were measured 4 weeks later,at the same time oral glucose tolerance test and insulin release test were performed. Results In the FSC group,body weight,abdominal circumference,blood pressure,visceral fat,plasma glucose and insulin level significantly increased than the NC group,plasma lipid disorders increased and significant insulin resistance occurred. Conclusion High fat and high salt could successfully induced obesity,hypertension,dyslipidemia and impaired glucose tolerance.