Effect of different-dose atorvastatins on serum High sensitive C-reactive protein、Interleukin-10 and Monncyte chemoattractant protein-1 levels in post-intervention patients with coronary stenting
10.3760/cma.j.issn.1008-6706.2010.16.008
- VernacularTitle:不同剂量阿托伐他汀对冠状动脉内支架植入术后血清单核细胞趋化蛋白-1、白细胞介素-10和高敏C反应蛋白水平的影响
- Author:
Jiangwei MA
;
Zengyong QIAO
;
Li ZHANG
;
Hua CAO
;
Yuan TAO
;
Huajin LIU
;
Dinhong JIN
;
Cuiqing ZHU
- Publication Type:Journal Article
- Keywords:
Angioplasty,transluminal,percutaneous coronary;
C-Reactive prolein;
Monocyte chemoatt ractant proteins;
Interleukin-10;
Atorvastatin
- From:
Chinese Journal of Primary Medicine and Pharmacy
2010;17(16):2176-2178
- CountryChina
- Language:Chinese
-
Abstract:
Objective To Discuss the impacts of different dosage of atorvastatirs on serum hsCRP,IL-10 and MCP-1 levels on post-intervention patients with coronary stenting. Methods 93 post-intervention patients with coronary stenting were selected and randomly divided into 3 groups.Each group took different dosage of oral atorvastatins after the operation for more than one week.The dosage for each group was 10 mg,20 mg and 40 mg,respectively.Each patient was phlebotomized for three times,which are 24 hours before the operation,24 hours after the operation and one week after the operation.Serum MCP-1,IL-10 and hs-CRP levels were measured by enzyme linked immunosorbent assay(ELISA)and immunoturbidimetry(ITM). Results Serum hs-CRP and MCP-1 levels of post-intervention patients were significantly higher than those of pre-intervention.This illustrated that the serum hsCRP and MCP-1 levels were closely related to PCI.Serum hs-CRP and MCP-1 levels decreased in those patients one week after operation which proves they are negatively correlated with the dosage of atorvastatins.There was no statistic evidence to prove the correlation between different dosage of atorvastatins and the level of serum IL-10.The ratio of MCP-1/IL-10 at 24h post-intervention patient was significantly higher than pre-intervention,which proves the ratio was negatively correlated with the dosage of atorvastatins. Conclusion Atorvastatins decreases serum MCP-1 and hs-CRP levels after PCI.Serum MCP-1 and hs-CRP levels were negatively correlated with the dosage of atorvastatins.
