A study on the relationship between the polymorphisms in Interleukin 1 receptor accessory protein-like 2 and cognitive ability of the children in Qin-Ba mountainous region
10.3760/cma.j.issn.1674-6554.2010.09.002
- VernacularTitle:白细胞介素1受体辅助蛋白样2基因多态性与秦巴山区儿童认知能力相关性研究
- Author:
Pingyuan GONG
;
Xiaocai GAO
;
Bo HE
;
Kejin ZHANG
;
Zijian ZHENG
;
Shaoping HUANG
;
Fuchang ZHANG
- Publication Type:Journal Article
- Keywords:
Cognitive ability;
Intelligence quotient factor;
Interleukin 1 receptor accessory proteinlike 2;
Polymorphic variation
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2010;19(9):772-775
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between interleukin 1 receptor accessory protein-like 2 (IL1RAPL2) gene and cognitive abilities of children in Qin-Ba mountainous region. Methods Four tagged SNPs (rs5962434,rs5916817, rs3764765 and rs5962298 ) in IL1RAPL2 were selected, and then genotyped by PCR-SSCP method in a 320 children sample aged from six to fourteen years old. Results The results showed the rs5962434, rs5916817 ,rs3764765 and rs5962298 had no deviations from Hardy-Weinberg equilibrium (P＞0.05),and there were no significant statistical differences in the average psychometric scores of general cognitive ability(P=0.81,0.53,0.79,0.90) ,verbal comprehension (P=0.58,0.47,0.69,0.87 ) ,memory and concentration (P=0.69,0.35,0.76,0.90) among the compared genotype groups at each of the markers. Furthermore,the results also indicated that the four SNPs were not associated with perceptual organization in males and females respectively (P = 0.70,0.85,0.76,0.90,0.65,0.22,0.98,0.90 ). Conclusion The present work suggests that the human general cognitive ability, the three cognitive factors of C-WISC scale are not influenced manifestly by the genetic variations in IL1RAPL2.
