Clinical effect and pathogenesis of tiopronin in treating acute pancreatitis complicated with liver damages
10.3760/cma.j.issn.1673-4904.2010.25.003
- VernacularTitle:硫普罗宁治疗急性胰腺炎肝损害临床疗效及机制探讨
- Author:
Chunyan LUAN
;
Zhigang LIU
;
Hongmei ZHOU
;
Yinhua ZHANG
;
Cunxin ZHAO
- Publication Type:Journal Article
- Keywords:
Thiopronine;
Pancreatitis;
Liver failure
- From:
Chinese Journal of Postgraduates of Medicine
2010;33(25):6-8
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical effect and pathogenesis of tiopronin in treating acute pancreatitis complicated with liver damages. Methods Eighty-one patients with acute pancreatitis complicated with liver damages were randomly divided into two groups. The control group (40 cases) received routine treatment, and the treatment group (41 cases ) received routine treatment and tiopronin. The liver function, pancreatic enzyme indexes and C-reactive protein (CRP), the length of hospital stay was recorded. Results After 8 days' treatment, the liver function improved, and the levels of pancreatic enzyme indexes and CRP were decreased significanfly in both groups, and these changes were more obvious in treatment group (P <0.05). The length of hospital stay of mild acute pancreatitis in treatment group was significantly shorter than that in control group [ (8.6 ± 2.7 ) d vs. ( 13.8 ± 3.5 ) d ] (P < 0.05 ). Conclusions Tiopronin has beneficial effects in treating acute pancreatitis complicated with liver damages,and it has a therapeutic effect in acute pancreatitis at the same time. The mechanism may be related with the inhibition of inflammatory mediators, oxygen free radicals scavenging and other effects.
