Research progress in conditionally replicative adenoviruses targeting cancer stem cells
10.3760/cma.j.issn.1673-422X.2010.09.002
- VernacularTitle:靶向肿瘤干细胞的条件增殖腺病毒研究进展
- Author:
Lanzhou NAI
;
Lijun MAO
;
Jiacun CHEN
- Publication Type:Journal Article
- Keywords:
Neoplastic stem cells;
Conditionally replicative adenoviruses;
Gene therapy
- From:
Journal of International Oncology
2010;37(9):646-648
- CountryChina
- Language:Chinese
-
Abstract:
Cancer stem cells (CSC) are capable of self-renewal and differentiation, properties that are critical to tumor growth, metastasis, and radioresistance. Eradication of CSC is the key to the success of cancer therapy. Conditionally replicative adenoviruses(CRAd) are a novel class of viral agents which selectively replicate in tumor cells but not in normal cells. CRAd can specifically target and eradicate CSC ,representing a promising cure for cancer.
