The influence of NF-κB protein expression in the periaqueductal gray matter induced by sumatriptan in migraine animal model
10.3760/cma.j.issn.1006-7876.2010.10.013
- VernacularTitle:舒马曲坦对偏头痛模型大鼠中脑导水管周围灰质区核转录因子-κB表达的影响
- Author:
Rongfei WANG
;
Shengyuan YU
- Publication Type:Journal Article
- Keywords:
Migraine;
Periaqueductal gray;
NF-kappaB;
Sumatriptan
- From:
Chinese Journal of Neurology
2010;43(10):725-728
- CountryChina
- Language:Chinese
-
Abstract:
Objectiye To investigate the possible mechanism of sumatriptan in treating migraine.Methods Migraine model rat was electrically stimulated at cerebral dura mater in superior sagittal sinus (SSS) to induce migraine.Each of 10 male SD rats were randomly selected into groups of normal control (no intervention), pseudo-stimulation group ( no electrical stimulation), stimulation group ( no treatment after stimulation), saline group (treated with saline after migraine stimulation ) and sumatriptan group ( treated with sumatriptan after migraine stimulation).The neurons expressing NF-κB in periaqueductal gray matter (PAG) were evaluated in each group by immnunostaining.Results The numbers of NF-κB immunoreactive positive neurons were 179.5 ± 14.9 in sumatriptan group, 497.8 ± 20.6 in saline group,508.7 ± 30.8 in stimulation group, 112.9 ± 10.7 in pseudo-stimulation group and 111.7 ± 15.7 in normal group.The stimulation group was higher than normal group, pseudo-stimulation group and sumatriptan group (F=944.78, P <0.05).Conclusions The NF-κB positive neurons were activated in the PAG by electric stimulation of the dura mater near the SSS.Sumatriptan can reduce the expression of NF-κB protein.
