MRI findings of nasopharyngeal carcinoma in patients presenting with ocular signs
10.3760/cma.j.issn.1005-1201.2010.10.008
- VernacularTitle:以眼科症状首诊的鼻咽癌MRI特征
- Author:
Bin JIANG
;
Zhenchang WANG
;
Junfang XIAN
- Publication Type:Journal Article
- Keywords:
Nasopharyngeal neoplasms;
Eye diseases;
Cranial nerve diseases;
Magnetic resonance imaging
- From:
Chinese Journal of Radiology
2010;44(10):1045-1048
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the MRI features of nasopharyngeal carcinoma (NPC) in patients who presented with ocular abnormalities. Methods The clinical signs and MRI features of Ⅲ, Ⅳ and/or Ⅵ cranial nerve involvement in 22 cases of histologically proved nasopharyngeal carcinoma were retrospectively analyzed. Results All 22 cases showed perineural tumor spread along the course of Ⅲ, Ⅳ and Ⅵ cranial nerve. Diplopia was the most common sign, occurred in 14/22 patients. The incidence of incomplete palsy of Ⅲ, Ⅳ and Ⅵ cranial nerve were 16/44, 7/44 and 4/44, respectively. There were four types of abnormal MRI findings: cavernous sinus thickening (10/44) and mass ( 16/44), superior orbital fissure enlargement (4/44) and abnormal signals (9/44), thickened oculomotor muscles with obscured adjacent fatty space and abnormal enhancement (10/44). The dynamic contrast enhancement patterns of the masses in cavernous sinus and orbital were the same as that of nasopharynx lesions; all appeared as rapid initial enhancement followed by a plateau phase. Conclusion Oculomotor nerve involvement can be the first clinical signs of NPC, and MRI can show the perineural extension along the Ⅲ, Ⅳ and Ⅵ cranial nerve in NPC.
