Effects of preoperative intravenous different doses of pantoprazole on acidity of gastric fluid
10.3760/cma.j.issn.0254-1416.2010.06.008
- VernacularTitle:术前静脉输注不同剂量泮托拉唑钠对患者术中胃液酸度的影响
- Author:
Fan YANG
;
Linlin GAO
;
Yanxin YUAN
;
Lingxin MENG
- Publication Type:Journal Article
- Keywords:
Benzimidazoles;
Premedication;
Gastric juice;
Hydrogen-ion concentration
- From:
Chinese Journal of Anesthesiology
2010;30(6):664-666
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of preoperative iv different doses of pantoprazole on acidity of gastric fluid in patients undergoing elective surgery. Methods Sixty ASA Ⅰ -Ⅲ patients aged 38-80 yr,weighing 44-72 kg undergoing elective surgery were randomly allocated into 3 groups (n = 20 each): group Ⅰ control (group C); group Ⅱ pantoprazole 40 mg(group P1) and group Ⅲ pantoprazole 80 mg(group P2). The patients received intravenous normal saline (NS) 100 ml, pantoprazole 40 and 80 mg in NS 100 ml respectively in group C, P1 and P2 at 30 min before surgery. Gastric content was aspirated using a gastric tube on the patients'arrival in the operating room and at 1,2 h and the end of surgery. The pH of the gastric fluid was measured. The adverse effects including dizziness, diarrhea, PONV and incidence of stress ulcer were recorded. Results The pH was significantly increased in group P1 and P2 as compared with control group but there was no significant difference in pH between group P1 and P2 . There were no significant difference in the incidence of stress ulcer and pH of the gastric fluid≤2.5 among the 3 groups. Conclusion Preoperative intravenous pantoprazole 40 mg can effectively increase pH of gastric juice and is helpful in reducing the incidence of stress ulcer and the risk of acid aspiration.
