Association of angiotensin Ⅱ type 1 receptor gene polymorphism with essential hypertension
10.3760/cma.j.issn.1008-6315.2010.10.014
- VernacularTitle:血管紧张素Ⅱ1型受体基因多态性与原发性高血压的关系
- Author:
Hongtao GONG
;
Fenghe DU
- Publication Type:Journal Article
- Keywords:
Angiotensin Ⅱ type 1 receptor;
Essential hypertension;
Gene polymorphism
- From:
Clinical Medicine of China
2010;26(10):1047-1049
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate whether angiotensin Ⅱ type 1 receptor(AT1R)gene polymorphism is associated with essential hypertension(EH). Methods A total of 200 hypertension patients and 192 normotensive controls were enrolled. The AT1R gene 1166A/C and -810A/T polymorphism were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-PFLP), and the association between the SNPs and the EH were analyzed statistically. Some biochemical index such as serum glucose (GLU) and total cholesterol (TC),triglyceride (TG), high density lipoprotein (HDL-C) and low density lipoprotein (LDL-C) were also measured. Results There was no significant difference between two groups of 1166A/C polymorphisms of AT1R gene(P ＞ 0.05 ). However, for the -810A/T polymorphism of AT1R gene, -810 AT and TT genotypes frequencies were significantly higher in EH patients than control (P = 0. 004). The -810T allele frequencies were higher in case than in control (22.5% vs. 11.5% ;P =0.000). We also found an association between EH and -810AT and TT genotypes by logistic regression analysis ( P = 0. 003 ), adjusted for other risk factors. The odds ratio was 2.57 (95% CI:1. 37 ～4. 84). Conclusions AT1R -810A/T polymorphism is associated with EH and -810T allele may be a risk factor of hypertension
