Clinical characteristics and prognosis of combined hepatocellular-cholangiocarcinoma
10.3760/cma.j.issn.1007-631X.2010.10.002
- VernacularTitle:混合型肝细胞-胆管细胞癌的临床特点及预后分析
- Author:
Yuxin ZHONG
;
Yipeng WANG
;
Jianxiong WU
;
Wei PEI
;
Weiqi RONG
;
Fan WU
;
Quan XU
;
Liguo LIU
;
Chengli MIAO
;
Ping ZHAO
- Publication Type:Journal Article
- Keywords:
Liver neoplasms;
Hepatectomy;
Survival analysis
- From:
Chinese Journal of General Surgery
2010;25(10):789-791
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical characteristics and analyze prognostic risk factors of combined hepatocellular-cholangiocarcinoma. Methods The clinical data of 19 cases of combined hepatocellular-cholangiocarcinoma admitted in our hospital from January 1999 to December 2009 were analyzed retrospectively. The survival function was analyzed by Kaplan-Meier. The possible prognostic risk factors were tested by χ2-test. Results Hepatocellular-cholangiocarcinoma was diagnosed by pathology in the 19 patients, among which hepatic tunic was infiltrated in 13 cases, peritoneum involved in 1 case, intravascular cancer embolus in 1 case. At that time lymphocyte nodes metastasis in 2 cases were found by regional lymphadenectomy in 7cases. The 1-year and 3-year survival rates were 61% and 42%,respectively. Prognosis of patients with tumor size ＞ 5 cm ( χ2 = 4. 392, P = 0. 036 ), history of heavy drinking ( χ2 = 11.010, P = 0.001 ) or intraoperative blood transfusion ( χ2 = 4. 645,P = 0. 031 ) were worse than others. Conclusion It was difficult to get correct preoperative diagnosis of combined hepatocellularcholangiocarcinoma. Tumor size, history of heavy drinking and blood transfusion were all prognostic related risk factors.
