Effect of Amniotic Membrane to Reduce Postlaminectomy Epidural Adhesion on a Rat Model.
10.3340/jkns.2011.49.6.323
- Author:
Hyu Jin CHOI
1
;
Kyoung Beom KIM
;
Young Min KWON
Author Information
1. Department of Neurosurgery, College of Medicine, Dong-A University, Busan, Korea. ymkwon@dau.ac.kr
- Publication Type:Original Article
- Keywords:
Human amniotic membrane;
Failed back surgery syndrome;
Epidural adhesion;
Laminectomy
- MeSH:
Amnion;
Animals;
Cicatrix;
Failed Back Surgery Syndrome;
Fibroblasts;
Fibrosis;
Humans;
Laminectomy;
Rats
- From:Journal of Korean Neurosurgical Society
2011;49(6):323-328
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: Epidural fibrosis and adhesion are the main reasons for post-laminectomy sustained pain and functional disability. In this study, the authors investigate the effect of irradiated freeze-dried human amniotic membrane on reducing epidural adhesion after laminectomy on a rat model. METHODS: A total of 20 rats were divided into two groups. The group A did not receive human amniotic membrane implantation after laminectomy and group B underwent human amniotic membrane implantation after laminectomy. Gross and microscopic findings were evaluated and compared at postoperative 1, 3 and 8 weeks. RESULTS: The amount of scar tissue and tenacity were reduced grossly in group of rats with human amniotic membrane implantation (group B). On a microscopic evaluation, there were less inflammatory cell infiltration and fibroblast proliferation in group B. CONCLUSION: This experimental study shows that implantation of irradiated freeze-dried human amniotic membrane reduce epidural fibrosis and adhesion after spinal laminectomy in a rat model.
