Risk factors for hepatic steatosis in patients with chronic hepatitis B:a case-control study

VernacularTitle:慢性乙型肝炎患者合并肝脂肪变性危险因素的病例对照研究
Author: Jing CHEN ; Jing DONG ; Haiduan LIN ; Jiaji JIANG
Publication Type:Journal Article
Keywords: Hepatitis B,chronic; Fatty liver; Risk factors
From: Chinese Journal of General Practitioners 2010;09(10):683-686
CountryChina
Language:Chinese
Abstract: Objective To investigate risk factors for hepatic steatosis in patients with chronic hepatitis B (CHB). Methods One hundred and eighty patients with biopsy-proven chronic hepatitis B were included in the study. Those with liver steatosis (61 from 93 cases) and those without it (61 from 87 cases)were matched on gender and age ( ± 3 years). Results Body mass index (BM I) was significantly higher in case group (24 ±3) than that in controls (22 ±3) (P ＜0.01 ). No significant difference was found in fasting plasma glucose, total cholesterol, triglycerides, urine acid, alanine aminotransferase, glutamyl transpeptidase and hepatitis B virus ( HBV ) DNA between the cases and controls ( all P ＞ 0. 05 ).Conditional logistic regression analysis with proportional hazard regression model statement by SPSS software showed that BMI was the only independent correlate to liver steatosis in patient with CHB ( OR = 1. 488, P ＜0. 01 ). Conclusions Liver steatosis in patients with CHB associates with BMI of the hosts, but does not correlate to their HBV DNA level.