Attenuated Salmonella as tumor vaccine vectors
10.3760/cma.j.issn.1673-422X.2010.09.003
- VernacularTitle:以减毒沙门菌为载体的肿瘤疫苗研究
- Author:
Fan ZHANG
;
Shulin LIU
- Publication Type:Journal Article
- Keywords:
Salmonella;
Neoplasms;
Bacteria vector
- From:
Journal of International Oncology
2010;37(9):649-651
- CountryChina
- Language:Chinese
-
Abstract:
Attenuated Salmonella can be used not only as live vaccines but also as vectors for exogenous genes. As vectors, attenuated bacteria can deliver genes directly to tumor tissues, leading to the expression of the cloned genes and induction of specific anti-tumor immunologic responses to inhibit tumor growth. Using attenuated Salmonella as a vector offers a new approach for vaccine development.
