Biological characteristics of IL-24 and mechanisms of its anti-tumor action
10.3760/cma.j.issn.1673-422X.2010.09.006
- VernacularTitle:IL-24的生物学特性及其抗肿瘤作用机制
- Author:
Di LIU
;
Xiaoqun XU
- Publication Type:Journal Article
- Keywords:
Interleukin-24;
Genes,tumor suppressor;
Gene expression regulation,neoplastic
- From:
Journal of International Oncology
2010;37(9):657-661
- CountryChina
- Language:Chinese
-
Abstract:
Studies have shown that IL-24 is the only cytokine capable of inhibiting tumor growth and neovascularization as well as stimulating immune system. IL-24 exerts its inhibition effects through pathways independent of p53, Rb, p16 and other tumor suppressor genes and has no effect on normal cells. IL-24 has emerged as a hot topic in cancer therapy research.
