Progress in Vav3 and breast cancer research
10.3760/cma.j.issn.1673-422X.2010.09.014
- VernacularTitle:Vav3与乳腺癌的关系
- Author:
Xin CHEN
- Publication Type:Journal Article
- Keywords:
Vav3 oncogene;
Breast neoplasms;
Signal transduction;
Receptors,estrogen
- From:
Journal of International Oncology
2010;37(9):686-688
- CountryChina
- Language:Chinese
-
Abstract:
Vav3 oncogene is a member of the Vav family. Vav3 protein contains multiple functional motifs and is involved in cancer development and progression through its role in various cellular signaling processes, including cytoskeleton organization, calcium influx, genetic transcription, cell transformation, proliferation and apoptosis. In addition, Vav3 interacts with estrogen receptor and enhances ERα-mediated signaling axis, therefore plays an important role in breast cancer.
