Study on anti-tumor effect of medicinal fungiPhellinus igniarius extracts
10.3760/cma.j.issn.1673-4246.2010.05.002
- VernacularTitle:桑黄提取物的抗肿瘤作用研究
- Author:
Zhigang JIAO
;
Rula SA
- Publication Type:Journal Article
- Keywords:
Fungiphellinus igniarius extracts;
Anti-tumor effect: MCF7;
OVCA2780
- From:
International Journal of Traditional Chinese Medicine
2010;32(5):391-393
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the inhibiting effects of phellinus igniarius extractive (PLE) on tumor growth of tumor-bearing mice in vivo, and the direct inhibiting action to human tumor in vitro. Methods ①Models of hepatoma,sarcoma, lung cancer in mice were established. Experiments in studying the effect of PLE on the above three animal models were repeated for three times. ②The suppression of cellular growth of human tumor was detected by MTT assay. Results PLE (250.500 and 1000 mg/kg, ig, d1 to d11) could inhibit the growth of H22 tumor cells in mice at the inhibitory rate of 57%,63% and 46%,respectively; slow down the growth of S180 tumor cells in mice at the inhibitory rate of 27.9%, 75%, and 31.2%,respectively; suppress the growth of Lewis lung cancer in mice at the inhibitory rate of 57.1%, 54.5%, 45.9%; and hold back the proliferation of MCF7 cells and OVCA2780 cells (P<0.01). Conclusion PLE (250.500 and 1000 mg/kg, ig, d1 to d11)could inhibit the growth of H22 tumor cells, S 180 tumor cells, and Lewis lung cancer in mice. PLE could significantly reduce the proliferation of MCF7 cells and OVCA2780 cells (P<0.05).