The value of serum ICTP in the early diagnosis, efficacy and prognosis of tumor bone metastasis

VernacularTitle:血清Ⅰ型胶原吡啶交联终肽对肿瘤骨转移的早期诊断效能、疗效观察及预后价值的分析
Author: Jianhong LU ; Guojun CHEN ; Changlin DONG ; Shunbin ZHU ; Qi CHEN ; Mei YUAN ; Yijun JIN
Publication Type:Journal Article
Keywords: ICTP; Tumor; Bone metastasis; Diagnostic potency; Efficacy; Evaluation of prognosis
From: Clinical Medicine of China 2010;26(7):679-682
CountryChina
Language:Chinese
Abstract: Objective To evaluate the serum pyridinoline cross-linked carboxyteminal telopeptide of type Ⅰ collagen ( ICTP) in the early diagnosis potency,efficacy and prognosis of tumor bone metastasis. Methods According to emission computed tomography(ECT) ,MRI and X-ray results,336 cases of tumor were divided into higher ICTP (5. 98 ± 1. 95μg/L ) than normal values. Twenty-two cases were identified bone metastasis through PET/CT examination. 26 cases were identified bone the effective cases decreased from( 13. 22 ± 4.65)μg/L (before treatment) to (7. 18 ±3. 54)μg/L (after treatment) (t = 10. 076,P = 0. 000). Conclusions Serum ICTP is helpful for the early diagnosis, screening and efficacy evaluation of tumor bone metastasis. It could be used for monitoring the occurrence of tumor bone metastasis and its prognosis.