Mechanism of impaired angiogenesis after Diabetic limb ischemia
10.3760/cma.j.issn.1673-4203.2010.10.021
- VernacularTitle:糖尿病肢体缺血后血管新生能力受损机制探讨
- Author:
Qingbao GUO
;
Xiangyu ZHOU
;
Sen SHI
;
Yanzheng HE
- Publication Type:Journal Article
- Keywords:
Diabetes;
Angiogenesis;
Progenitor cells;
Non- enzymatic glycation end products;
Wnt signaling pathway
- From:
International Journal of Surgery
2010;37(10):705-709
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic vascular disease is a major complication of diabetes, which is characterized by the formation of collateral vessels of serious damage to systemic disease. Substantial evidence have shown that timpaired endothelial progenitor cell function, non-enzymatic glycation end products accumulate, and Wnt signaling pathway dysfunction may be an important mechanism of impaired angiogenesis after the diabeticlimb ischemic. This paper is to make a study of its mechanism, and to provides a new strategy for diabetes therapeutic angiogenesis.
