Application of recombinant human growth hormone combined with early enteral nutrition in severely burned patients
10.3760/cma.j.issn.1008-6706.2010.17.004
- VernacularTitle:早期肠内营养联合生长激素在危重烧伤患者救治中的应用研究
- Author:
Zuhuang WU
;
Bing SON
;
Guoyang CHEN
;
Yanwu ZHUO
- Publication Type:Journal Article
- Keywords:
Burn;
Early enteral nutrition;
Recombinant human growth hormone;
Burn sepsis
- From:
Chinese Journal of Primary Medicine and Pharmacy
2010;17(17):2311-2313
- CountryChina
- Language:Chinese
-
Abstract:
Objective To summarize the therapeutic effect of recombinant human growth hormone and early enteral nutrition in severely burned patients. Methods 35 cases were randomly divided into group EN and group PN.Group EN was treated with early enteral nutrition(EEN) and recombiant human growth hormone(rhGH) ,while group PN was given parenteral nutrition. The plasma levels of pre-albumin (PA), C-reactive protein (CRP) , tunmor necrosis factor α(TNFα) ,fasting blood glucose(FBG) were measured after burn injury. Comparision was made in length of hospital stay, wound healing time,incidence of burn sepsis, gastrointestinal stress ulcer bleeding and enteral nutrition intoleranc. Results Incidence of burn sepsis,gastrointestinal stress ulcer bleeding and enteral nutrition intoleranc in group EN were significantly lower than those of group PN(P ＜ 0.05). The serum levels of CRP、TNFα、FBG in group EN were significantly lower than those of group PN (P ＜ 0.05). The serum PA was decreased at all times in two periods and was markedly decreased in group EN(P ＜0.05). Length of hospital stay and the healing time of donor site, deep partial thickness burn wound, skin transplantion area were significantly shortened in group EN compared with group PN. Conclusion Early enteral nutrition was beneficial for the improving of nutrition state of the burn patients,and the reduction of the incidence of burn sepsis and the hospitalization time.
