Effects of Edaravone on the levels of hs-CRP and D-dimer in Patients with Acute Cerebral infarction

VernacularTitle:依达拉奉对急性脑梗死患者超敏C-反应蛋白及D-二聚体的影响
Author: Jinming DU ; Zongting YAN
Publication Type:Journal Article
Keywords: cerebral infarction; hs-CRP; D-dimer
From: Chinese Journal of Primary Medicine and Pharmacy 2010;17(17):2316-2317
CountryChina
Language:Chinese
Abstract: Objective To investigate the effects of edaravone on the levels of high sensitivity C-reactive protein(hs-CRP) and D-dimer in patients with acute ischemic cerebral infarction. Methods A total of 86 patients with acute ischemic cerebral infarction were randomly divided and assigned into therapy group and control group. The control group was given a routine treatment of acute ischemic stroke. The therapy group was treated with edaravone in addition to the routine treatment. hs-CRP and D-dimer were measured before and after treatment. Barthel index(BI) and Chinese stroke Scale(CSS) of two groups were assessed before treatment and after treatment. Results The levels of hs-CRP and D-dimer were deceased after treatment. After the start of edaravone ,the levels of hs-CRP and D-dimer of therapy group were significantly lower than those of control group(P ＜0.05). The scores of CSS and BI of two groups improved after treatment,and scores of CSS and BI of the therapy group were better than those of the control group(P＜ 0.05). Conclusion Edaravone could decrease the levels of hs-CRP and D-dimer and is beneficial to improve neurofunctional recovery.