Study of CysC and Scr used to evaluate acute renal injury of patients with shock
10.3760/cma.j.issn.1671-0282.2010.10.020
- VernacularTitle:胱抑素C及肌酐监测休克患者急性肾损伤的研究
- Author:
Qiang LI
;
Weiping WANG
;
Jieyu FANG
;
Jianghui LIU
;
Keke WANG
- Publication Type:Journal Article
- Keywords:
Cystatin C;
Serum creatinine;
Shock;
Acute kidney injury
- From:
Chinese Journal of Emergency Medicine
2010;19(10):1074-1077
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the roles of cystatin C (CysC) and serum creatinine (Scr) in acute renal injury of patients with shock. Method A total of 71 patients with shock, 42 male and 29 female, were enrolled from February 2006 to June 2007. Patients with kidney disease or renal insufficiency were excluded. All of patients were assigned to 4 groups as per the duration of shock. The blood samples were taken from patients for measurements of CysC and Scr during the periods of 1 hr,2 hr,and 4 hr of shock and 72 hr and 7 days after correction of shock. The corrected GFR (cGFR) and decreased GFR (dGFR) were calculated. The levels of Scr and dGFR could be used to classify the acute renal injury into stages according to the Acute Kidney Injury Diagnosis Criteria. The positive detection rates of different methods were compared. The levels of CysC, Scr and cGFR were statistically analyzed. Data were studied by using Pearson's correlation analysis, Results The elevation of CysC appeared sooner than that of Scr in all shock patients. Contrarily, the high level of CysC lowered to normal level much slower than that of SCR after correction of shock. The CysC increased 1 hour after shock. The GFR was negatively correlated with CysC and Scr, especially in the early stage of shock. Conclusions The renal dysfunction appears in the early stage of shock. The CysC assayed is more sensitive in the stage 1 of renal injury than Scr.
