Study on stability of compatibility of Qingkailing and Dexamethasone Sodium Phosphate Injection
10.3760/cma.j.issn.1673-4246.2010.04.044
- VernacularTitle:清开灵与地塞米松磷酸钠注射液的配伍稳定性考察
- Author:
Weizhen KANG
;
Manbo CHEN
- Publication Type:Journal Article
- Keywords:
Qingkailing Injection;
Dexamethasone Sodium Phosphate Injection;
pH;
Stability of insoluble particles
- From:
International Journal of Traditional Chinese Medicine
2010;32(4):357-358
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the stability of Qingkailing injection, Qingkailing and dexamethasone sodium phosphate injection in compatibility of 0.9% sodium chloride injection, 5% glucose injection, 10% glucose injection, glucose and sodium chloride injection. Methods Such changes as appearance, pH, and insoluble particulate were observed at the room temperature after mixing together of the Qing Kai Ling Injection, Qingkailing and dexamethasone sodium phosphate injection with 0.9% sodium chloride injection, 5% glucose injection, 10% glucose injection, glucose and sodium chloride injection. Results Dexamethasone sodium phosphate did not affect the stability of the Qingkailing. The PH value of Qingkailing stayed at 6.4～7.0 after being mixed with four kinds of solutions. The compatibility solutions had no significant change in appearance, met to the requirements of the Chinese Pharmacopoeia insoluble particle detection specification Conclusion Qing Kai Ling Injection, Qing Kai Ling and dexamethasone sodium phosphate injection can be used together with solvent compatibility of 0.9% sodium chloride injection, 5% glucose injection, 10% glucose injection, glucose and sodium chloride injection within 8 h.
