Clinical significance in testing urinary NK cells in patients with glomerulonephritis

VernacularTitle:尿自然杀伤细胞检测在肾小球肾炎中的临床意义
Author: Guozhen ZHU ; Rongshan LI ; Lei ZHU ; Yue QI ; Weimin YU ; Jiazhi KANG
Publication Type:Journal Article
Keywords: Natural killer cell; Flowcytometry; Glomerulonephritis
From: Clinical Medicine of China 2010;26(7):693-695
CountryChina
Language:Chinese
Abstract: Objective To evaluate the clinical significance of detecting urinary natural killer(NK) cells in patients with general types of glomerulonephritis. Methods The contents of urinary NK cells from 54 patients with glomerulonephritis were measured by flowcytometry,while all patients were classified into two groups including acute proliferation group and none-acute proliferation group by renal biopsy results. The content of urinary NK cells was compared between the two groups. Results The content of urinary NK cells in acute proliferative glomerular disease group were( 14. 8 ±3. 3)% (30 cases) ,which was significantly higher than that of(21. 6 ±2. 9)% (24 cases) in the non-acute proliferative glomerular patients(P<0.05). Conclusions Decreasing of the contents of NK cells in urine may be an indirect indicator of the activity of glomerulonephritis.