Pretransplantation HBV DNA load and post liver transplant HCC recurrence in HCC patients undergoing liver transplantation
10.3760/cma.j.issn.1007-631X.2010.09.008
- VernacularTitle:肝癌患者术前HBV DNA定量水平与肝移植术后肝癌复发关系的探讨
- Author:
Minru LI
;
Shuhong YI
;
Changjie CAI
;
Guoying WANG
;
Huimin YI
;
Guihua CHEN
- Publication Type:Journal Article
- Keywords:
Liver transplantation;
Carcinoma,hepatocellular;
Hepatitis B virus
- From:
Chinese Journal of General Surgery
2010;25(9):717-719
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between hepatitis B virus (HBV) concentration and hepatocellular carcinoma (HCC) recurrence in HCC patients undergoing orthotopic liver transplantation (OLT). Methods 148 HCC patients associated with HBV infection undergoing OLT were enrolled in the study.Survival analysis was performed using the Kaplan-Meier method.Cox multiple regression analysis was performed to determine the parameters predicting HCC recurrence. Results Survival rates at 1,3 and 5 years were 86%,72% and 72%,respectively,and disease-free survival rate were 79%,71% and 54%,respectively.In this series 43 patients suffered from HCC recurrence.The recurrence rate was 29.1%(43/148),with the mean recurrence time being (13.16 ± 14.17) months (1 ～ 54 months).Exceeding Milan criteria (HR = 9.89; 95% CI 2.30 ～ 42.52; P = 0.002) and pretransplant HBV DNA level ＞ 5log10copies/ml (HR = 2.26; 95% CI 1.01 ～ 5.04; P = 0.047) were significant independent predictors for posttransplant HCC recurrence. Conclusion High HBV DNA load before transplantation is statistically associated with recurrence of HCC after liver transplantation.
