Clinical significance of endothelin-1 and transforming growth factor-β in the newborns with respiratory distress.
10.3760/cma.j.issn.1008-6315.2010.10.036
- VernacularTitle:呼吸窘迫新生儿血浆内皮素-1和转化生长因子-β的变化及其意义
- Author:
Li XING
;
Zhiwei HUANG
;
Dongdong SUN
- Publication Type:Journal Article
- Keywords:
Respiratory distress;
Endothelin-1;
Transforming growth factor-β
- From:
Clinical Medicine of China
2010;26(10):1099-1101
- CountryChina
- Language:Chinese
-
Abstract:
Objective To measure the serum levels of endothelin-1 (ET-1) and transforming growth factor-β(TGF-β) in the newborns with respiratory distress and investigate its clinical significance. Methods Newborns with respiratory distress hospitalized into the Newborn Intensive Care Unit were included. The serum levels of ET-1 and TGF-β were all detected with ELISA in the first six hours,3,7,14 and 28 days after birth. Results The highest levels of ln ( 1 + ET-1 ) and ln ( 1 + TGF-β) were obtained from newborns with diagnosis as meconium aspiration syndrome ( 1.95 ± 1.02) ng/L and ( 1.51 ±0.99) ng/L,respectively) in the samples obtained in the first six hours after birth, and these were statistically different from those of the control group ( P ＜ 0. 05 ). Following were obtained for newborns with respiratory distress syndrome ( ( 1.52 ± 0.74 ) ng/L and ( 1.13 ± 0. 48 ) ng/L, t = 2.28,2. 13,respectively). After oxygen treatment, ET-1 levels obtained in the first six hours of life decreased gradually in the following days (P ＜0.05 ). Conclusions The measurements of ET-1 and TGF-β levels will help in differentiating diagnosis of the respiratory distress of newborns. The ET-1 levels will help to assess the therapy effectiveness and prognosis.
