Intervention of Zhuanggu granule on IL-1β and TNF-α level of the patients with osteoarthritis

VernacularTitle:壮骨颗粒对退变性膝骨性关节炎关节液中IL-1β、TNF-α水平的干预作用
Author: Jixiao LANG ; Dexi CHEN ; Peilin YU ; Jingming ZHAO ; Zhijun XING
Publication Type:Journal Article
Keywords: Knee degenerated osteoarthritis; Zhuangu granule; IL-1β; TNF-α
From: International Journal of Traditional Chinese Medicine 2010;32(5):400-401
CountryChina
Language:Chinese
Abstract: Objective To investigate the influence of Zhuanggu granule on the concentration of IL-1β and TN-F-α in knee cavity of patients with knee degenerated osteoarthritis. Methods A total of eighty patients with knee degenerated osteoarthritis were recruited into a Zhuanggu granule group (30 cases), a Sulphuric acid Glucosamine group (15 cases) and a Sodium Hyaluronate group (15 cases) according to Doll grouping method. After all groups were treated for 4 weeks, the changes of concentration of IL-1β and TNF-α was detected before and after the therapy Results After the treatment, the concentration of IL-1β and TNF-α in Zhuangu granule group was significantly lower than the other two groups (Sodium Hyaluronate and sulphuric Glucosamine group). Conclusion Zhuangu Granule could influence the concentration of IL-1β and TNF-α in patients of knee degenerated osteoarthritis.