Intervention of Zhuanggu granule on IL-1β and TNF-α level of the patients with osteoarthritis
10.3760/cma.j.issn.1673-4246.2010.05.006
- VernacularTitle:壮骨颗粒对退变性膝骨性关节炎关节液中IL-1β、TNF-α水平的干预作用
- Author:
Jixiao LANG
;
Dexi CHEN
;
Peilin YU
;
Jingming ZHAO
;
Zhijun XING
- Publication Type:Journal Article
- Keywords:
Knee degenerated osteoarthritis;
Zhuangu granule;
IL-1β;
TNF-α
- From:
International Journal of Traditional Chinese Medicine
2010;32(5):400-401
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence of Zhuanggu granule on the concentration of IL-1β and TN-F-α in knee cavity of patients with knee degenerated osteoarthritis. Methods A total of eighty patients with knee degenerated osteoarthritis were recruited into a Zhuanggu granule group (30 cases), a Sulphuric acid Glucosamine group (15 cases) and a Sodium Hyaluronate group (15 cases) according to Doll grouping method. After all groups were treated for 4 weeks, the changes of concentration of IL-1β and TNF-α was detected before and after the therapy Results After the treatment, the concentration of IL-1β and TNF-α in Zhuangu granule group was significantly lower than the other two groups (Sodium Hyaluronate and sulphuric Glucosamine group). Conclusion Zhuangu Granule could influence the concentration of IL-1β and TNF-α in patients of knee degenerated osteoarthritis.