The Expression and clinical Significance of p53、p16 protein in advanced gastric carcinoma

VernacularTitle:进展期胃癌组织中p53、p16蛋白的表达及意义
Author: Zhen YANG ; Shishi QIAO ; Hongxiang LIU ; Jinqiao ZHOU
Publication Type:Journal Article
Keywords: Stomach neoplasms; Protein p53; Protein p16
From: Chinese Journal of Primary Medicine and Pharmacy 2010;17(18):2458-2459
CountryChina
Language:Chinese
Abstract: Objective To investigate the expressions of p53,p16 protein and the clinical significance in advanced gastric carcinoma. Methods The expressions of p.53 ,p16 were detected by using immunohistochemistry in 24 specimens of normal gastric mucosa and 55 specimens of gastric carcinoma. Results The positive rate of p53 ,p16 in normal gastric mucosa and gastric carcinoma tissues were 0,100% ;67.3% ,30. 9%, respectively (P <0. 05). The positive rate of p53, p16 in non-differentiated、low- differentiated and moderate- differentiated 、high- differentiated gastric carcinoma tissues were 80. 0% ,56.7% and 48. 0% ,56. 0% ,respectively(P <0. 05). Conclusions The abnormal expressions of p53 and p16 play an important role in the course and prognosis of gastric carcinoma. The positive expression of p53 was correlated with the degree of defferentiation of gastric carcinoma. No correlation between the expression of p16 and grade of differentiation was observed.