Diagnostic value of (1,3)-β-D-glucan assay and galactomannan test for invasive fungal infection in patients of acute radiation sickness
10.3760/cma.j.issn.0254-5098.2010.05.008
- VernacularTitle:血浆(1-3)-β-D-葡聚糖和半乳甘露聚糖检测在急性放射病侵袭性真菌感染防治中的临床意义
- Author:
Jing WANG
;
Hongmei JING
;
Jijun WANG
;
Yan LIU
;
Wei ZHAO
;
Yongzhong NING
;
Jie ZHANG
;
Xiaoyan KE
- Publication Type:Journal Article
- Keywords:
Acute radiation sickness (ARS);
Invasive fungal infection (IFI);
(1,3)-β-D-glucan;
Galactomannan
- From:
Chinese Journal of Radiological Medicine and Protection
2010;30(5):527-530
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the diagnostic values of (1,3)-β-D-glucan (G) and galactomannan (GM) for invasive fungal infection (IFI) in patients of acute radiation sickness (ARS).Methods Samples of periogeral blood,pharyngeal secretion,urine,and feces were collected from 316patients with ARS and suspected to suffer from IFI,192 males and 124 females,aged 60.50(1-96),with the underlying diseases of blood or respiration systems.Platelia Aspergillus EIA kit was used to detect the plasma BG (G test),and ELISA was used to detect the serum GM (GM test).Fungal culture and bacterial culture were performed.Results The positive rates of G test,GM test,and fungal culture were 36.33%,35.84% ,and 34.18% respectively,but the positive rate of fungal culture of blood sample was 1/316 only.Pearson correlation analysis showed that G test,GM test and fungal culture test were positively correlated with IFI clinical diagnosis respectively (x2 = 0.564,0.357,0.727,P ＜ 0.05).Conclusions Easy to operate,rapid,and highly sencitive,G test and GM test can be used as adjunctive methods for early IFI diagnosis in ARS patients.
