Radiological protection effect of vanillin derivative VND3207 against radiation-induced cytogenetic damage in mouse bone marrow cells
10.3760/cma.j.issn.0254-5098.2010.05.015
- VernacularTitle:香兰素衍生物VND3207对小鼠骨髓细胞遗传损伤的防护效应研究
- Author:
Chuangao WANG
;
Li WANG
;
Pingkun ZHOU
;
Zhongwen WANG
;
Yongzhe HU
;
Haiming JIN
;
Xueqing ZHANG
;
Ying CHEN
- Publication Type:Journal Article
- Keywords:
Vanillin derivative;
γ-ray;
Polychromatophilic erythroblasts micronuclei;
Chromosome aberration;
Mitotic index;
Radioprotective agent
- From:
Chinese Journal of Radiological Medicine and Protection
2010;30(5):558-560
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the protection of vanillin derivative VND3207 on the cytogenetic damage of mouse bone marrow cell induced by ionizing radiation.Methods BALB/c mice were randomly divided into five groups:normal control group,2 Gy dose irradiation group,and three groups of 2 Gy irradiaiton with VND3207 protection at doses of 10,50 and 100 mg/kg,respectively.VND3207 was given by intragastric administration once a day for five days.Two hours after the last drug administration,the mice were irradiated with 2 Gy γ-rays.The changes of polychromatophilic erythroblasts micronuclei (MN),chromosome aberration (CA) and mitosis index (MI) of mouse bone marrow cells were observed at 24 and 48 h after irradiation.Results Under the protection of VND3207 at the dosages 10,50,100 mg/kg,the yields of poly-chromatophilic erythroblasts MN and CA of bone marrow cells were significantly decreased(t = 2.36-4.26,P ＜ 0.05),and the marrow cells MI remained much higher level compared with the irradiated mice without drug protection (t = 2.58,2.01,P ＜ 0.05).The radiological protection effect was drug dose-dependent,and the administration of VND3207 at the dosage of 100 mg/kg resulted in reduction by 50% and 65% in the yields of MN and CA,respectively.Conclusions VND3207 had a good protection effect of on γ-ray induced cytogentic damage of mouse bone marrow cells.
