Application of continuous subcutaneous insulin infusion in desensitization for allergy to recombinant human insulin
10.3760/cma.j.issn.1674-635X.2010.02.005
- VernacularTitle:持续皮下胰岛素输注在人胰岛素过敏患者脱敏治疗中的应用
- Author:
Naishi LI
;
Weigang ZHAO
;
Hongbo YANG
;
Wenhui LI
;
Xiaoling ZOU
;
Hui PAN
;
Lianglu WANG
;
Hongding XIANG
- Publication Type:Journal Article
- Keywords:
Insulin allergy;
Insulin analogue;
Desensitization;
Continuous subcutaneous insulin infusion
- From:
Chinese Journal of Clinical Nutrition
2010;18(2):84-86
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the values of continuous subcutaneous insulin/rapid insulin analoguc infusion in desensitization for allergy to recombinant human insulin. Methods Two patients allergic to recombinant human insulin received desensitization therapy by continuous subcutaneous insulin lispro infusion. The diluted insulin lispro solution was pumped with initial basal rate of O. O1 U/h, and the basal rate and insulin lispro concentration increased gradually until the insulin dosage for clinical treatment was reached. After that, continuous subcutaneous insulin lispro infusion was replaced by regimen of insulin lispro subcutaneous injection plus oral hypoglycemic agents. Results Local wheals were not observed in both two patients during continuous subcutaneous insulin lispro infusion or during bolus subcutaneous injection of insulin lispro after desensitization. Conclusion The desensitization therapy by continuous subcutaneous insulin/rapid insulin analogue infusion can be applied for allergy to recombinant human insulin.
