Changes of some trace elements and nutritional proteins in children with acute lymphoblastic leukemia and acute myeloid leukemia at stages of onset
10.3760/cma.j.issn.1674-635X.2010.01.006
- VernacularTitle:儿童急性淋巴细胞白血病和急性粒细胞白血病发病初期微量元素及营养相关蛋白的变化
- Author:
Jing WANG
;
Ying WU
;
Yijue CHEN
;
Jian WANG
;
Huaiyuan LI
;
Qihua FU
- Publication Type:Journal Article
- Keywords:
Leukemia;
Trace element;
Nutrition;
Protein
- From:
Chinese Journal of Clinical Nutrition
2010;18(1):19-23
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of serum trace elements and nutritional proteins in children with acute lymphoblastic leukemia and acute myeloid leukemia at the stage of onset. Methods Serum levels of cuprum, zinc, iron, magnesium, phosphorus, calcium, ceruloplasmin, ferritin, transferrin, lactate dehydrogenase, total protein, albumin, hemoglobin, and erythrocytes were detected in 73 patients with acute lymphoblastic leukemia, 26 patients with acute myeloid leukemia at stages of onset, and 30 healthy controls using methods including atomic absorption spectrometry, nophelometry assay, dry chemical method, and/or chemiluminescence method. The differences of these indicators among these three groups were analyzed by t test. Results Serum levels of all detected elements except for zinc and phosphorus were significantly different between the onset groups and the control group (P ＜ 0.05 ). Serum levels of cuprum, magnesium, iron, ferritin, ceruloplasmin, and lactate dehydrogenase in the onset groups were significantly higher than those in control group ( all P ＜ 0.05 ). On the contrary, calcium, transferrin, total protein, albumin, hemoglobin, and erythrocyte count were significantly lower in the onset groups than those in control group (P ＜ 0.05). Serum iron, cuprum, zinc, and their metabolism were significantly different between acute lymphoblastic leukemia group and acute myeloid leukemia group ( P ＜ 0.05 ).Conclusion Serum levels of some trace elements and nutritional proteins are disordered and out of balance in chil dren with acute lymphoblastic leukemia and acute myeloid leukemia at stages of onset.
