Research advances in the pathogenesis of pediatric parenteral nutrition associated cholestasis
10.3760/cma.j.issn.1674-635X.2010.01.012
- VernacularTitle:小儿肠外营养相关胆汁淤积机制的研究进展
- Author:
Jing LI
;
Wei CAI
- Publication Type:Journal Article
- Keywords:
Parenteral nutrition;
Cholestasis;
Pathogenesis
- From:
Chinese Journal of Clinical Nutrition
2010;18(1):48-51
- CountryChina
- Language:Chinese
-
Abstract:
Parenteral nutrition associated cholestasis (PNAC) mainly occurs in children. Currently identified risk factors include premature infants, lack of enteral feeding, repeated infections, and toxicity or nutrient deficiency of parenteral nutrition solution. Recent studies have shown that nuclear receptor-mediated bile acid transporter may be the key site of PNAC pathogenesis, in which some cytokines play important roles. New anti-cholestatic therapy based on the regulation of expression of these molecules may prevent end-stage liver disease caused by PNAC.
