Clinical efficacy of atorvastatin in patients with lacunar infarctions and influence on cerebrovascular reactivity
10.3760/cma.j.issn.1008-6706.2010.18.007
- VernacularTitle:阿托伐他汀治疗腔隙性脑梗死的临床疗效及对脑血管反应性的影响
- Author:
Siwei FANG
;
Xiaoyun ZHANG
- Publication Type:Journal Article
- Keywords:
Brain infarction;
Atorvastatin;
Lacunar infarctions
- From:
Chinese Journal of Primary Medicine and Pharmacy
2010;17(18):2462-2463
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical efficacy of atorvastatin in patients with lacunar infarctions (LI) and influence on cerebrovascular reactivity(CVR). Methods 60 patients with LI were randomly divided into observation group and control group. The patients of control group were given aspirin treatment, patients of observation group were given atorvastatin combination with aspirin therapy. The breath-holding index(BHI) before and after treatment was calculated. After continuous treatment for 3 months the clinical efficacy was evaluated. Results The total effective rate of the observation group was 90. 0% ,it was significantly higher than that of the control group(73.3% ),compared with the control group the difference was significant( x2 = 10. 428 ,P < 0. 05). The bilateral BHI of observation group significantly increased, compared with per-treatment and control group the difference was significant ( t =9. 455,6. 135 ,all P < 0. 05 ) ,but the bilateral BHI of control group had no significant difference compared with pertreatment ( P ＞ 0. 05 ). Conclusion Atorvastatin could effectively improve CVR in patients with LI. Therefore, atorvastatin had great significance for the prevention of stroke.
