PTEN and thyroid tumor
10.3760/cma.j.issn.1673-4203.2010.10.015
- VernacularTitle:PTEN与甲状腺肿瘤
- Author:
Fengyan YIN
;
Detao YIN
- Publication Type:Journal Article
- Keywords:
Phosphatase and tensin homomlogy deleted on ten;
Thyroid cancer;
Tumor suppressor
- From:
International Journal of Surgery
2010;37(10):687-690
- CountryChina
- Language:Chinese
-
Abstract:
A tumor suppressor gene at 10q23.3, designated PTEN, encoding a dual specificity phosphatase with lipid and protein phosphatase activity, has been shown to play an important role in the pathogenesis of a variety of human cancers and sporadic tumor. In this paper, we reviewed the construction and function of PTEN, and the mechanism of activation in cancer especially in thyroid carcinoma.
