Clinical Study of Different Regimens of Chemotherapies for Elderly Patients with Advanced Gastric Cancer
10.3760/cma.j.issn.1008-6706.2010.17.030
- VernacularTitle:不同化疗方案治疗老年晚期胃癌的临床研究
- Author:
Jing CHEN
;
Yuan LIN
;
Yuqin DUAN
;
Yi ZHANG
- Publication Type:Journal Article
- Keywords:
Aged;
Stomach neoplasms;
Antineoplastic combined chemotherapy protocols
- From:
Chinese Journal of Primary Medicine and Pharmacy
2010;17(17):2365-2367
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the clinical effects and adverse reactions of different regimens of chemotherapies for elderly patients with advanced gastric cancer. Methods 95 elderly patients with advanced gastric cancer were randomly divided into 3 groups. The regimens of OLF,OX and HCF were used to treat 38 patients,25 patients and 32 patients respectively. The short-term curative effects and side effects on tumor were gradeded according to the criteria formulated by WHO. The curative effects and adverse reactions were assessed and the time of disease progression was calculated at least 2 cycles after chemotherapy. Results The efficacy rate was 55.26%, 60. 00% and 53. 13% respectively,and statistical analysis showed no significant difference(P ＞ 0.05). The time of disease progress was 23,30 and 24 weeks respectively, there were significant differences (P ＜ 0.05). The major side effect were neutropenia, gastrointestinal reactions, and were able to be tolerated without a chemotherapy-related death. Conclusion Three regimens of chemotherapies had better curative effects and mild side effects for elderly patients with advanced gastric cancer,and could improve the quality of life of the patients,and are worth of clinical promotion.
