The influence of 4 ℃ cold saline on ultra structure of myocardium of swine after cardiopulmonary resuscitation
10.3760/cma.j.issn.1671-0282.2010.10.005
- VernacularTitle:4 ℃盐水输注低温对猪心肺复苏后心肌组织超微结构的影响
- Author:
Yi LU
;
Chunsheng LI
- Publication Type:Journal Article
- Keywords:
Ventricular fibrillation;
Cardiopulmonary resuscitation;
Myocardium;
Ucltrastructure;
Hypothermia;
Pig
- From:
Chinese Journal of Emergency Medicine
2010;19(10):1027-1030
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the myocardial injury attributed to cardiopulmonary resuscitation, and to evaluate the impact of 4 ℃ saline perfusion on the ultra structure of myocardium. Method Twelve Pekimg white swine were induced to make models of ventricular fibrillation by direct current shock. Cardiopulmonary resuscitation was initiated 4 minutes after ventricular fibrillation established, and 10 swine survived from resuscitation. These swine were randomly(random number ) divided into hypothermia group ( n = 5) ( 4 ℃ saline infusion to lower the temperature) and control group ( n = 5). Haemodynamics were monitored. And ultra structure of myocardium was observed under electron microscope 24 hours later. The Mann-Whitney test was used to compare the consecutive variables of 2 samples. Results The damage to the ultra structure of myocardium, myofilaments and mitochondria, was found in the control group, while that to a much lesser extent in the hypothermia group was observed. Conclusions After cardiopulmonary resuscitation, 4 ℃ saline infusion has a protective effect on myocardium.
