Comparison of HLA antibody production in living donor and cadaveric transplant
10.3760/cma.j.issn.1673-4203.2010.10.006
- VernacularTitle:亲属与非活体肾移植术后抗HLA抗体和肾功能的比较
- Author:
Baoxiang JIA
;
Xiuhong XU
;
Ye TIAN
- Publication Type:Journal Article
- Keywords:
Kidney transplant;
Living donor transplant;
Panel reactive antibody
- From:
International Journal of Surgery
2010;37(10):662-665
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the Panel reactive antibody (PRA) producing incidence in living and cadaveric transplant for forecasting long term survival. Methods Retrospectively analyze post-transplant PRA of 48 living transplant patients ( December 2003-Sepdtember 2007 ), and 258 cadaveric transplant patients( Feburary 2003-June 2007 ), which in both groups were all PRA negative in pre-transplant. PRA was detected using LAT-1240 (OneLambda) and QUICKSCREE&BSCREEN (GTI). Serum creatine/urea nitrogen level was provided by clinical laboratory. Results Four recipients in 48 living transplant patients showed PRA positive(8.33% ), while 62 receipients in 258 cadaveric transplant patients showed PRA positive(24.03% ) ( P ＜0.05 ). Three recipients in 35 male living donor transplant patients showed PRA positive(8.57% ) ,while 23.03% PRA positive in male cadaveric transplant patients (P ＜0.05). In females, 1out of 13 living donor transplant patients showed HLA-Ⅱ positive, whereas 20 out of 106 in cadaveric transplant patients( 18.87% ) ( P ＜ 0. 05). Conclusion The incidence of HLA antibody production was much higher in cadaveric transplant patients than that in those of living donor transplant.
