Animal experiment and clinical study of Argon plasma coagulator in simple enucleation for small renal cell carcinoma
10.3760/cma.j.issn.1000-6702.2010.10.004
- VernacularTitle:氩气刀在腹腔镜下小肾癌剜除术中应用的动物实验及临床研究
- Author:
Changwen ZHANG
;
Yong XU
;
Kuo YANG
;
Baojie MA
;
Baomin QIAO
;
Ting ZHANG
;
Wenguang FAN
;
Yan LIU
;
Haijie XIE
;
Yang SHI
- Publication Type:Journal Article
- Keywords:
Argon;
Carcinoma,renal cell;
Laparoscopes;
Animal experimentation;
Clinical study
- From:
Chinese Journal of Urology
2010;31(10):662-665
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the feasibility and clinical effect of Argon plasma coagulator in simple enucleation for small renal cell carcinoma. Methods On the basis of successful performing the animal experience of coagulating therapy on the wound tissue during partial nephrectomy with Argon plasma coagulator in rabbit models, 10 cases of simple enucleation for small renal cell carcinoma with Argon plasma coagulator were accomplished. Results Both with the standard of stopping bleeding of wound tissue by Argon plasma coagulator and with the standard of re-spraying the wound tissue for 2 s after stopping bleeding using Argon plasma coagulator, the depth of wound tissue necrosis without blocking the renal pedicle is deeper than that with blocking the renal pedicle(P=0. 012 and P=0. 002, respectively).If the wound tissue was re-sprayed for 2 s after stopping bleeding by Argon plasma coagulator, the depth of the wound tissue necrosis without blocking the renal pedicle was deeper than that just with blocking the renal pedicle(P=0. 007 and P=0. 002,respectively). In the part of application in clinical, all procedures were successfully completed. The mean operative time was 163 min (range, 100-210 min) and mean blood loss was 230 ml (range, 100-400 ml). Drainage tube was pulled out 1 month after operation in 1 case for being allergic to absorbable hemostatic gauze, and the mean pulling drainage tube out time in others was 4. 2 d (range, 3-5 d). During a mean follow-up of 22 months (range, 10-38 months), no local tumor recurrence and distant metastasis was found. Conclusion Argon plasma coagulator can be used in simple enucleation for small renal cell carcinoma, and the clinical effectiveness is ideal.
