The significance and expression of CD147 and NF-κB in esophageal squamous cell carcinoma
10.3760/cma.j.issn.1008-1372.2010.09.005
- VernacularTitle:CD147、NF-κB在食管鳞状细胞癌组织中的表达及意义
- Author:
Lina XIONG
;
Zhifan XIONG
;
Yan TU
- Publication Type:Journal Article
- Keywords:
Antigens,CD147/ME;
NF-kappa B/ME;
Esophageal neoplasms/ME;
Carcinoma,squamous cell/ME
- From:
Journal of Chinese Physician
2010;12(9):1171-1173
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of extracellular matrix metalloproteinase inducer (CD147), nuclear factor kappa B (NF-κB) in esophageal squamous cell carcinoma tissue and probe their relationship to invasion and metastasis of esophageal carcinoma. Methods Immunochemical staining was performed to detect the expression of CD147 and NF-κB protein in 40 cases of esophageal carcinoma tissues and 40 cases of normal control. Results The positive rate of CD147 and NF-κB in esophageal carcinoma tissues and in adjacent noncancerous tissues were 77.5%/87.5% Vs 25%/42. 5%, P<0.05.The positive rate of their prophase and metaphase-advanced stage esophageal carcinoma tissues were 33.3%/90.3% Vs 55.6%/96.8%, P<0.05..The positive rate of non-metastatic and metastatic esophageal carcinoma tissues were 28.6%/87.9% Vs 42.9%/97%, P<0.05.Conclusions Our results suggested that the increased expression of CD147 and NF-κB contributed to tumor angiogenesis in esophageal squamous cell carcinoma, which might be through the common pathway.