Application of hyperinsulinemic euglycemic clamp in the diagnosis and treatment of newly-onset diabetic patients

Tao Yuan; Weigang Zhao; Yong FU; Yingyue Dong; Lian Duan; Yan Jiang; Ou Wang; Miao YU; Jianping XU

Return

Application of hyperinsulinemic euglycemic clamp in the diagnosis and treatment of newly-onset diabetic patients

VernacularTitle:正常血糖高胰岛素钳夹法在新发糖尿病患者诊治中的应用价值
Author: Tao YUAN ; Weigang ZHAO ; Yong FU ; Yingyue DONG ; Lian DUAN ; Yan JIANG ; Ou WANG ; Miao YU ; Jianping XU
Publication Type:Journal Article
Keywords: Hyperinsulinemic euglycemic clamp; Insulin sensitivity; Diabetes mellitus; Insulin intensive therapy
From: Chinese Journal of Clinical Nutrition 2010;18(2):77-79
CountryChina
Language:Chinese
Abstract: Objective To evaluate the application value of hyperinsulinemic euglycemic clamp in the diagnosis and treatment of newly-onset diabetic patients. Methods Totally 11 newly-onset diabetic inpatients (10 patients with type 2 diabetes mellitus and 1 patient with latent autoimmune diabetes of adulthood) who were diagnosed in the Department of Endocrinology of Peking Union Medical College Hospital from January 2009 to August 2009 were included in this study. Hyperinsulinemic euglycemic clamp was applied to measure the glucose disposal rate (M value). Afterwards insulin pump therapy was applied and the total insulin dosage per day to get to the target of the fasting and postprandial blood glucose was calculated. Final]y the relationships between insulin dosage per day and the M value, body mass index (BMI) , fasting blood glucose, fasting insulin level were separately analyzed. Results The insulin dosage was only negatively correlated with M value (r = - 0. 83, P = 0. 003), and was not significantly correlated with BMI (r = 0.54, P = 0.106), fasting blood glucose (r = - 0. 16, P =0. 657) , and fasting insulin (r = 0. 16, P = 0. 659). The formula of insulin dosage and M value according to the mathematic model as follows: insulin dosage per day = - 3. 327 M + 49. 849. Conclusion Hyperinsulinemic euglycemic clamp can effectively evaluate the insulin sensitivity in the newly-onset type 2 diabetic patients, and thus can be a useful tool in deciding the clinical insulin dosage.